Shasha Zheng, Ph.D.
Associate Professor of Nutrition Founder for Master of Science in Human Molecular and Medical Nutrition; Co-Founder for Bachelor of Science in Nutrition and Food Science
Office Phone: (951) 552-8386 E-mail: email@example.com Office Location: Health Science Campus H137 Office Hours: By appointment
|Ph.D.||Human Molecular Nutrition / Epigenetics||University of Illinois at Urbana-Champaign||2011|
|Postdoc Fellow||Immunology / Inflammatory Bowel Diseases||Yale University School of Medicine|
|M.A.||Medical Nutrition Sciences / Epidemiology||Boston University School of Medicine||2007|
BS in Nutrition and Food Science
NFS100 Basic Nutrition for Sports Performance
NFS101 Introduction to Nutrition
NFS104 Introduction to Foods and Preparation
NFS220 Food Culture & Society
NFS300 Life Cycle Nutrition
NFS320 Nutrition Biochemistry
NFS340 Public Health Nutrition
NFS400 Special Topic in Nutrition
NFS455 Medical Nutrition Therapy I
NFS465 Medical Nutrition Therapy II
NFS475 Advanced Human Nutrition
NFS491 Molecular Nutrition Research
MS in Human Molecular and Medical Nutrition
NFS520 Nutritional Biochemistry
NFS555 Medical Nutrition Therapy I
NFS565 Medical Nutrition Therapy II
NFS557 Advanced Human Nutrition
NFS585 Nutrigenomics Research
Academic Areas & Scholarly Interests
Current Research Projects: Effects of natural plants/components and as therapeutic supplements on the prevention and treatment of diabetes, hypertension, hyperlipidemia, chronic inflammatory diseases, depression, lupus; Discovery of the novel SUMOylation inhibitor as anti-influenza virus agents; Effects of maternal nutrition on fetal developmental programing and offspring health outcome via epigenetic regulation; Immunological consequences of transcription factor interactions on cytokine response, combined genetic and epigenetic mechanisms on the risk for developing human immune system disease.
Research, Presentations, & Publications
G Way, Z Xiong, G Wang, H Dai, S Zheng, A García-Sastre, J Liao. A Novel SUMOylation Site in the Influenza A Virus NS1 Protein Identified with a Highly Sensitive FRET Assay. Journal of Biotechnology 2020; 323: 121-127.
CW Su, CY Chen, L Jiao, SR Long, T Mao, Q Ji, S O’Donnell, C Stanton, S Zheng, WA Walker, BJ Cherayil, HN Shi. Helminth-Induced and Th2-Dependent Alterations of the Gut Microbiota Attenuate Obesity Caused by High-Fat Diet. Cellular and Molecular Gastroenterology and Hepatology 2020 in press
ZS Vrobel, S Zheng. Understanding microbial influence on mental health. Archives of Nutrition and Food Science 2020; 1: 1-4.
C Hariharan, FZ Kadayifci, J Li, J Liao, S Zheng. Development of High Sensitive and Quantitative Fret Based Biosensor to Detect Autophagy Cell Death Pathway and real time assay for determining Atg4A kinetics. Journal of Biotechnology and Bioscience 2020 in press
FZ Kadayifci, AM Onat, H Shi, S Zheng. Latest Nutritional Approaches in Fibromyalgia. Nutrition Research Reviews 2020 in press
G Way, Z Xiong, G Wang, H Dai, S Zheng, A García-Sastre, J Liao. A high-Sensitive and Quantitative FRET (qFRET) Method for Critical SUMOylation Site Identification. MethodsX 2020 in press
H Dai, G Ramirez, S Zheng. Dietary Minerals Measurement in Normal versus Obese Native American Adolescents. Journal of Racial and Ethnic Health Disparities 2020; 7: 769-775.
FZ Kadayifci, S Zheng and YX Pan. Molecular Mechanisms Underlying the Link between Diet and DNA Methylation. International Journal of Molecular Sciences 2018; 19: 4055-4057.
H Dai, R Song, M Barth, S Zheng. Dietary Nutrient Intake and Obesity Prevalence among Native American Adolescents. International Journal of Public Health Science 2018; 7: 114-119.
A Fu, X Xu, YL Mao, H Chen, S Zheng, W Li, and L Li. Echinacea purpurea Extract Polarizes M1 Macrophages in Murine Bone Marrow-Derived Macrophages Through the Activation of JNK. Journal of Cellular Biochemistry 2017; 118: 2664-2671.
MC Perez, BD Knisley, GE Crosby, MM Barth, S Zheng. Obesity Prevalence and Dietary Intake of Antioxidants in Native American Adolescents. International Journal of Public Health Science 2016; 5: 31-33.
S Zheng. Phytonutrient and bioactivity analysis of traditionally used Native American edible plants. Journal of Nutrition and Food Sciences 2016; 6: 3 suppl.
Y Liu, Y Shen, S Zheng and J Liao. A novel robust quantitative Förster resonance energy transfer assay for protease SENP2 kinetics determination against its all natural substrates. Molecular BioSystems 2015; 11: 3407-3414. (This has been listed as the Top 1 Research Article in Top 20 Best Articles on the journal, in the Domain of 26486594, 2015)
S Zheng, M Hedl, C Abraham. Twist1 and Twist2 contribute to cytokine downregulation following chronic NOD2 stimulation of human macrophages through the coordinated regulation of transcriptional repressors and activators. Journal of Immunology 2015; 195: 217-226.
S Zheng, M Hedl, C Abraham. TAM receptor-dependent regulation of SOCS3 and MAPKs contributes to pro-inflammatory cytokine downregulation following chronic NOD2 stimulation of human macrophages. Journal of Immunology 2015; 194: 1928-1937.
M Hedl, S Zheng and C Abraham. The IL18RAP Region Disease Polymorphism Decreases IL-18RAP/IL-18R1/IL-1R1 Expression and Signaling through Innate Receptor-Initiated Pathways. Journal of Immunology 2014; 192: 5924-5932.
S Zheng, C Abraham. NFκB1 Inhibits NOD2-Induced Cytokine Secretion through ATF3-Dependent Mechanisms. Molecular and Cell Biology 2013; 33: 4857-71.
S Zheng, Q Li, R Borhan, Z Balluff, Y Zhang, H Chen and Y-X Pan. Histone deacetylase 3 (HDAC3) participates in the transcriptional repression of the p16 (INK4a) gene in mammary gland of the female rat offspring exposed to an early-life high-fat diet. Epigenetics 2012; 7: 183-190.
S Zheng, M Rollet, KF Yang, Y-X Pan. A gestational low-protein diet represses p21(WAF1/Cip1) expression in the mammary gland of offspring rats through promoter histone modifications. British Journal of Nutrition 2012; 108: 998-1007.
S Zheng, M Rollet, Y-X Pan. Protein Restriction during Gestation Alters Histone Modifications at the Glucose Transporter 4 (GLUT4) Promoter Region and Induces GLUT4 Expression in Skeletal Muscle of Female Rat Offspring. Journal of Nutritional Biochemistry 2012; 23: 1064-1071.
S Zheng, D Iglesias-Gato, JN Flanagan, L Jiang, T Sakaki, S Nakabayashi, A Kittaka, NK LeBrasseur, G Norstedt1, TC Chen. The C-2 substituted 19-nor-1alpha,25-dihydroxyvitamin D3 analog, MART-10, has enhanced chemotherapeutic potency in PC-3 prostate cancer cells. Journal of Steroid Biochemistry & Molecular Biology 2011; 127: 269-275.
S Zheng, M Rollet, Y-X Pan. Maternal Protein Restriction during Pregnancy Induces CCAAT/enhancer-binding protein (C/EBPβ) Expression through the Regulation of Histone Modification at Its Promoter Region in Female Offspring Rat Skeletal Muscle. Epigenetics 2011; 6: 161-170.
S Zheng, Y-X Pan. Histone modifications, not DNA methylation, cause transcriptional repression of p16 (CDKN2A) in the mammary glands of offspring of protein-restricted rats. Journal of Nutritional Biochemistry 2011; 22: 567-573.
JN Flanagan, S Zheng, KC Chiang, A Kittaka, T Sakaki, S Nakabayashi, X Zhao, RA Spaniaard, KS Persons, JS Mathieu, MF Holick, TC Chen. Evaluation of 19-nor-2alpha-(3-hydroxypropyl)-1alpha, 25-dihydroxyvitamin D3 as a therapeutic agent for androgen-dependent prostate cancer. Anticancer Research 2009; 29: 3547-53.
TC Chen, KS Persons, S Zheng, J Mathieu, MF Holick, YF Lee, B Bao, MA Arai, A Kittaka. Evaluation of C-2-substituted 19-nor-1alpha,25-dihydroxyvitamin D3 analogs as therapeutic agents for prostate cancer. Journal of Steroid Biochemistry & Molecular Biology 2007; 103:717-720.
Invited Books & Chapters
Book Title: Epigenetics of Metabolism
Editors: Yuan-Xiang Pan & Shasha Zheng
Estimated year of publication: 2021
Chapter 3: Lipid Metabolism and Epigenetics
Chapter Authors: Shasha Zheng, Fatma Zehra, Raquel Martinez, Madelyn Jayne Bradley, Haining Shi.
Book Title: Fish and Fish Oil in Health and Disease Prevention
Editors: Susan K Raatz and Douglas M Bibus
Year of publication: 2016
Chapter 23. Fish, Fish Oil and Liver Cancer
Authors: Shasha Zheng and Tai C. Chen. Shasha Zheng authored the content on pages 249-262.
Book Title: Nutrition, Epigenetic Mechanisms, and Human Disease
Editors: Nilanjana Maulik and Gautam Maulik
Publisher: CRC Press
Year of publication: 2011
Chapter 10. Maternal Nutrition, Intrauterine Development and Disease Risks in the Offspring through Epigenetic Regulation of Gene Expression.
Authors: Yuan-Xiang Pan, Rita Strakovsky, and Shasha Zheng. Shasha Zheng authored the content on pages 237-250.
Presentations & Keynote Speaker & Chairman
S Zheng. Impact of Combination of Native American Plants with Traditional Chinese Herbs as Therapeutic Supplements on the Prevention, Management and Treatment of Type II Diabetes. International Conference on Nutrition, Obesity & Food technology 2019 (oral presentation).
H Dai, GE Ramirez, G Way, J Liao, S Zheng. Dietary Minerals Measurement in Normal versus Obese Native American Adolescents. Experimental Biology 2019 (poster presentation) FASEB Journal 2019.
H Dai, G Ramirez, G Way, J Liao, S Zheng. Dietary Minerals Measurement in Normal Versus Obese Native American Adolescents. Inaugural Annual Molecular and Translational Symposium on Translational Medicine Activities at UCR 2019 (poster presentation).
H Dai1, Z Xiong, G Way, J Liao, S Zheng. SUMOylation Sites Determination by a High Sensitive FRET Assay. Experimental Biology 2019 (poster presentation) FASEB Journal 2018; 32: 812.43
H Dai, R Song, M Barth, S Zheng. Native American Adolescent Obesity and Nutrient Intake. Experimental Biology 2018 (poster presentation) FASEB Journal 2018; 32: 812.43
H Dai, R Song, M Barth, S Zheng. Native American Adolescent Obesity and Nutrient Intake. CBU Student Research Colloquium 2018 (oral presentation).
C Hariharan, FZ Kadayifci, J Liao, S Zheng. High Sensitive FRET Based Assay To Detect Apoptosis And Autophagy Cell Death Pathways. The 18th Annual UC Systemwide Bioengineering Symposium Research Symposium “Translating Discovery into Health Technology” at UCLA 2017 (poster presentation).
H Dai, Z Xiong, G Way, J Jiang, X Dong, J Liao, S Zheng. Discovery of the novel SUMOylation inhibitor as anti-influenza virus agents. CBU Student Research Colloquium 2017 (Best Poster Award)
S Zheng, M Barth, D McCarthy, J Liao, J Adams, Y Hu. Phytonutrient and bioactivity analysis of traditionally-used Native American edible plants. Global Biotechnology Congress 2016 (Chairman for Pharmaceutical Biotechnology Session and Marine Biotechnology Session)
S Zheng, M Perez, G Crosby, C Dussell, B Knisely, Y Hu, L Carothers, M Barth. Antioxidants in Native American plants. 5th European Nutrition and Dietetics Conference 2016 (poster presentation).
S Zheng, G Crosby, B Knisley, M Perez, M Barth. Antioxidants Study in Native American Plants. Food Chemistry and Technology 2015 (Keynote Speaker).
G Crosby, B Knisley, M Perez, M Barth, S Zheng. Dietary Intake of Antioxidants including Vitamins C, E, and Lycopene Among Normal Weight and Obese Native American Adolescents. American Public Health Association 2015 (oral presentation).
S Zheng, G Crosby, B Knisley, M Perez, M Barth. Dietary Intake of Antioxidants including Vitamins C, E, and Lycopene Among Normal Weight and Obese Native American Adolescents. Experimental Biology 2015 (poster presentation). FASEB Journal 2015; 29: LB361
G Crosby, B Knisley, M Perez, M Barth, S Zheng. Dietary Intake of Antioxidants including Vitamins C, E, and Lycopene Among Normal Weight and Obese Native American Adolescents. Institute of Food Technologists 2015 (poster presentation).
K Valencia, G Crosby, B Knisley, M Perez, M Barth, S Zheng. Dietary Intake of Essential Minerals including Magnesium, Potassium and Iron in Normal Weight and Obese Native American Adolescents. Institute of Food Technologists 2015 (poster presentation).
M Perez, G Crosby, B Knisley, M Barth, S Zheng. Dietary Fiber Intake in Normal Weight and Obese Native American Adolescents. Institute of Food Technologists 2015 (poster presentation).
B Knisley, G Crosby, M Barth, S Zheng. Anthropometric indicators for assessing health risk of obesity in Native American adolescents and exploratory data analysis. Obesity 2014 (oral presentation).
S Zheng and C Abraham. NFkB1 Inhibits NOD2-Induced Cytokine Secretion through ATF3-Dependent and -Independent Mechanisms. IMMUNOLOGY 2013 AAI Annual Meeting abstract #1644073 (poster presentation).
S Zheng, Y-X Pan. Epigenetic Modifications Cause Transcriptional Repression of p21 Gene in Mammary Gland in the Offspring of Protein-Restricted Rats. Experimental Biology 2010 (oral presentation). FASEB Journal 2010; 24: 344.5
S Zheng, M Unander, Y-X Pan. Maternal Protein Restriction Alters Histone Modifications and Glucose Transporter 4 Expression in Female Rat Skeletal Muscle during Postnatal Development. Experimental Biology 2009 (poster presentation). FASEB Journal 2009; 23: 724.2
S Zheng, Y-X Pan. Oral intake of genistein changes DNA methylation at the promoters of rat colon genes. Experimental Biology 2008 (poster presentation). FASEB Journal 2008; 22: 885.6
M Unander, S Zheng, Y-X Pan. Maternal diet programs muscle glut4 expression in rat offspring. UIUC Undergraduate Research Symposium 2008 abstract #25 (poster presentation)
S Zheng, KS Persons, J Mathieu, MF Holick, YF Lee, B Bao, A Kittaka, TC Chen. Biological activity of 19-nor-1a, 25-dihydroxyvitamin D3 analogs for prostate cancer treatment. Boston University Medical School Evans Research Day 2006 abstract #38 (poster presentation)