Shasha Zheng, Ph.D.
Associate Professor of Nutrition
Office Phone: (951) 552-8386 E-mail: email@example.com Office Location: Health Science Campus H137 Office Hours: Tuesday and Thursday 12-5pm
|Ph.D.||Human Molecular Nutrition / Epigenetics||University of Illinois at Urbana-Champaign||2011|
|M.A.||Medical Nutritional Sciences / Clinics||Boston University School of Medicine||2007|
Postdoc Fellow in Immunology, Yale University School of Medicine 2011-2014
NFS101 Introduction to Nutrition
NFS104 Introduction to Foods and Preparation
NFS200 Life Cycle Nutrition
NFS220 Food Culture & Society
NFS320 Nutrition Biochemistry
NFS340 Public Health Nutrition
NFS400 Special Topic on Nutrition
NFS450 Medical Nutrition Therapy
NFS475 Advanced Human Nutrition
NFS491 Molecular Nutrition Research
Academic Areas & Scholarly Interests
Current research projects include: Discovery of the novel SUMOylation inhibitor as anti-influenza virus agents; The impact of Native American plants as therapeutic supplements on the prevention and treatment of hypertension, hyperlipidemia and chronic inflammatory diseases; Immunological consequences of transcription factor interactions, combined genetic and epigenetic mechanisms on the risk for developing human immune system disease; Effects of maternal supplements on fetal developmental programing and offspring health outcome
▪ Applied NIH R15 grant 2018 as PI, The novel SUMOylation inhibitor as anti-influenza virus agents
▪ Applied NIH R15 grant 2018 as PI, Maternal Immunology and Offspring Allergy
▪ Applied BMRP at CCFA grant as PI, Native American plants as therapeutic supplements for the treatment of IBD (inflammatory bowel disease)
▪ Research collaborative institutions: UC Riverside Bourns College of Engineering, Harvard University Mucosal Immunology Laboratory, University of South California School of Pharmacy, University of Illinois at Urbana-Champaign Division of Human Nutrition, Boston University School of Medicine, Zhejiang University College of Animal Sciences
Research, Presentations, & Publications
H Dai H, R Song, M Barth, S Zheng. Dietary Nutrient Intake and Obesity Prevalence among Native American Adolescents. International Journal of Public Health Science 2018; 7: 114-119.
A Fu, X Xu, YL Mao, H Chen, S Zheng, W Li, and L Li. Echinacea purpurea Extract Polarizes M1 Macrophages in Murine Bone Marrow-Derived Macrophages Through the Activation of JNK. Journal of Cellular Biochemistry 2017; 118: 2664-2671.
MC Perez, BD Knisley, GE Crosby, MM Barth, S Zheng. Obesity Prevalence and Dietary Intake of Antioxidants in Native American Adolescents. International Journal of Public Health Science 2016; 5: 31-33.
S Zheng. Phytonutrient and bioactivity analysis of traditionally used Native American edible plants. Journal of Nutrition and Food Sciences 2016; 6: 3 suppl.
Y Liu, Y Shen, S Zheng and J Liao. A novel robust quantitative Förster resonance energy transfer assay for protease SENP2 kinetics determination against its all natural substrates. Molecular BioSystems 2015; 11: 3407-3414. (This article has been listed as the top 1 publication in the specific domain - Top 20 Articles, in the Domain of Article 26486594, Since 2015)
S Zheng, M Hedl, C Abraham. Twist1 and Twist2 contribute to cytokine downregulation following chronic NOD2 stimulation of human macrophages through the coordinated regulation of transcriptional repressors and activators. Journal of Immunology 2015; 195: 217-226.
S Zheng, M Hedl, C Abraham. TAM receptor-dependent regulation of SOCS3 and MAPKs contributes to pro-inflammatory cytokine downregulation following chronic NOD2 stimulation of human macrophages. Journal of Immunology 2015; 194: 1928-1937.
M Hedl, S Zheng and C Abraham. The IL18RAP Region Disease Polymorphism Decreases IL-18RAP/IL-18R1/IL-1R1 Expression and Signaling through Innate Receptor-Initiated Pathways. Journal of Immunology 2014; 192: 5924-5932.
S Zheng, C Abraham. NFκB1 Inhibits NOD2-Induced Cytokine Secretion through ATF3-Dependent Mechanisms. Molecular and Cell Biology 2013; 33: 4857-71.
S Zheng, Q Li, R Borhan, Z Balluff, Y Zhang, H Chen and Y-X Pan. Histone deacetylase 3 (HDAC3) participates in the transcriptional repression of the p16 (INK4a) gene in mammary gland of the female rat offspring exposed to an early-life high-fat diet. Epigenetics 2012; 7: 183-190.
S Zheng, M Rollet, KF Yang, Y-X Pan. A gestational low-protein diet represses p21(WAF1/Cip1) expression in the mammary gland of offspring rats through promoter histone modifications. British Journal of Nutrition 2012; 108: 998-1007.
S Zheng, M Rollet, Y-X Pan. Protein Restriction during Gestation Alters Histone Modifications at the Glucose Transporter 4 (GLUT4) Promoter Region and Induces GLUT4 Expression in Skeletal Muscle of Female Rat Offspring. Journal of Nutritional Biochemistry 2012; 23: 1064-1071.
S Zheng, D Iglesias-Gato, JN Flanagan, L Jiang, T Sakaki, S Nakabayashi, A Kittaka, NK LeBrasseur, G Norstedt1, TC Chen. The C-2 substituted 19-nor-1alpha,25-dihydroxyvitamin D3 analog, MART-10, has enhanced chemotherapeutic potency in PC-3 prostate cancer cells. Journal of Steroid Biochemistry & Molecular Biology 2011; 127: 269-275.
S Zheng, M Rollet, Y-X Pan. Maternal Protein Restriction during Pregnancy Induces CCAAT/enhancer-binding protein (C/EBPβ) Expression through the Regulation of Histone Modification at Its Promoter Region in Female Offspring Rat Skeletal Muscle. Epigenetics 2011; 6: 161-170.
S Zheng, Y-X Pan. Histone modifications, not DNA methylation, cause transcriptional repression of p16 (CDKN2A) in the mammary glands of offspring of protein-restricted rats. The Journal of Nutritional Biochemistry 2011; 22: 567-573.
JN Flanagan, S Zheng, KC Chiang, A Kittaka, T Sakaki, S Nakabayashi, X Zhao, RA Spaniaard, KS Persons, JS Mathieu, MF Holick, TC Chen. Evaluation of 19-nor-2alpha-(3-hydroxypropyl)-1alpha, 25-dihydroxyvitamin D3 as a therapeutic agent for androgen-dependent prostate cancer. Anticancer Research 2009; 29: 3547-53.
TC Chen, KS Persons, S Zheng, J Mathieu, MF Holick, YF Lee, B Bao, MA Arai, A Kittaka. Evaluation of C-2-substituted 19-nor-1alpha,25-dihydroxyvitamin D3 analogs as therapeutic agents for prostate cancer. Journal of Steroid Biochemistry & Molecular Biology 2007; 103:717-720.
Invited Book Chapters
Book Title: Fish and Fish Oil in Health and Disease Prevention
Editors: Susan K Raatz and Douglas M Bibus
Year of publication: 2016
Chapter 23. Fish, Fish Oil and Liver Cancer
Authors: Shasha Zheng and Tai C. Chen. Shasha Zheng authored the content on pages 249-262.
Book Title: Nutrition, Epigenetic Mechanisms, and Human Disease
Editors: Nilanjana Maulik and Gautam Maulik
Publisher: CRC Press
Year of publication: 2011
Chapter 10. Maternal Nutrition, Intrauterine Development and Disease Risks in the Offspring through Epigenetic Regulation of Gene Expression.
Authors: Yuan-Xiang Pan, Rita Strakovsky, and Shasha Zheng. Shasha Zheng authored the content on pages 237-250.
Church Membership & Activities
Riverside Baptist Church
The Church in Riverside
Calvary Community Church